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Creators/Authors contains: "Sun, Hui-Lung"

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  1. ; ; ; ; ; ; ; (, Bioorganic & Medicinal Chemistry Letters)
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  2. ; ; ; ; ; ; (, Chemical Communications)
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    The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23. 
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